Tag: GABA

Excitatory GABA:  observation versus experimental artifact

Bregestovski P and Bernard C (2012) Excitatory GABA: how a correct observation may turn out to be an experimental artifact. Front. Pharmacol.3:65. doi: 10.3389/fphar.2012.00065 Abstract The concept of the excitatory action of GABA during early development is based on data obtained mainly in brain slice recordings. However, in vivo measurements as well as observations made…



How does GABA behave in the intact brain?

Q: Dr. Zilberter, In your post at brainfuels.com, you cited several researchers and the closing phrase was: “The work undermined the role of depolarizing GABA”, commented Dr. Jean-Marc Goaillard from the Mediterranean University in Marseille”. First, does depolarizing equals inhibitory? Second, I just wondered:  why nobody directly measured GABA properties in the whole brain, in natural conditions? Wouldn’t it be…



Neuroprotective effects of energy substrates

Not only ketone bodies A shortage of ketones caused pathological changes in brain cells in brain slices (in vitro, 1) and in whole animals (in vivo, 2) resulting in abnormal (excitatory) behavior of GABA, the principal brain chemical helping to resist hyperactivity. In the article (1), the authors showed that not only ketone bodies, but also…