Studies from B. Hoebel lab suggest that access to CHO produces different addiction-like behaviors compared with access to fat (Avena and Gold, 2011; Bocarsly et al., 2011; Avena et al., 2012). Nutrient specificity in control of eating behavior was also shown in this lab (Berner et al., 2009). During the “sweet-chow” feeding protocol, rats compensated for the increased sucrose or glucose calories by decreasing chow intake. The authors (Avena et al., 2008) suggested that the increase in sugar intake, while not resulting in obesity, lead to an upregulation of affinity for opioid receptors, which in turn leads to the vicious circle of sugar abuse and might contribute to obesity.”
Zilberter T (2012) Food addiction and obesity: do macronutrients matter? Front. Neuroenerg. 4:7. doi: 10.3389/fnene.2012.00007
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